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Aldara cream treatment

Posted by ketrin.yohohono on October 18, 2020 at 4:35 AM

Treatment Options and Methods

  • Abstract
  • Diagnosis
  • Treatment Options and Methods
  • Adverse Effects of Treatment
  • Selection of Treatment
  • Special Management Issues
  • References

Untreated visible genital warts may resolve spontaneously, remain the same, or increase in size. aldara-cream.today The primary treatment goal is removal of symptomatic warts. Some evidence suggests that treatment also may reduce the persistence of HPV DNA in genital tissue, and therefore may reduce infectivity.1 However, there is currently no evidence that treatment of genital warts has a favorable impact on the incidence of cervical and genital cancer,1 and there have been no controlled studies on the effects of treatment of external genital warts and HPV transmission rates.8

The choice of therapy is based on the number, size, site, and morphology of lesions, as well as patient preference, treatment cost, convenience, adverse effects, and physician experience. Assuming that the diagnosis is certain, switching to a new treatment modality is appropriate if there is no response after three treatment cycles. Routine follow-up at two to three months is advised to monitor response to therapy and evaluate for recurrence.1

Treatment methods can be chemical or ablative. The mechanism of action for each treatment method is summarized in Table 1 ,9 and treatment courses and cycles are summarized in Table 2 . Typical response rates, adverse effect rates, and recurrence risks are summarized in Table 3 8 – 13; the response rate for all treatments is approximately 60 to 90 percent, and the response rate for placebo is zero to 50 percent.8 , 11

What Is Imiquimod and How Does It Work?

Imiquimod is available under the following different brand names: Aldara and Zyclara.

Dosages of Imiquimod:

Adult and Pediatric dosages:

 

  • 2.5% (Zyclara) (adults only)
  • 3.75% (Zyclara)
  • 5% (Aldara)

 

Dosage Considerations – Should be Given as Follows:

 

  • Indicated for topical treatment of clinically typical, nonhyperkeratotic, nonhypertrophic actinic keratoses on the face or scalp inimmunocompetent adults
  • Zyclara 2.5% or 3.75%: Apply daily to skin of affected area (either entire face or balding scalp) for two 2-week treatment cycles separated by 2-week no-treatment period
  • Aldara 5%: Apply 2 times a week for 16 weeks to one defined treatment area (contiguous area less than 25 cm²;); examples of dosing schedules include Monday and Thursday or Tuesday and Friday

 

External Genital Warts

 

  • Indicated for the treatment of external genital and perianal warts/condyloma acuminate
  • Zyclara 3.75%: Apply as thin film to entire treatment area and rub in until cream is no longer visible; may wash with mild soap and water after 8 hours of application; use 1 packet or 1 full actuation of pump
  • Aldara 5%: Apply 3 times a week until total clearance of warts or for a maximum of 16 weeks; examples of application schedules are Monday, Wednesday, Friday or Tuesday, Thursday, Saturday; use 1 packet only for each application

 

 

  • Indicated for the treatment of external genital and perianal warts/condyloma acuminata
  • Children under 12 years: Safety and efficacy not established

 

Children 12 years or older:

 

  • Zyclara 3.75%: Apply as thin film to entire treatment area and rub in until cream is no longer visible; may wash with mild soap and water after 8 hours of application; use 1 packet or 1 full actuation of pump
  • Aldara (5%): Apply 3 times a week until total clearance of warts or for a maximum of 16 weeks; examples of application schedules are Monday, Wednesday, Friday or Tuesday, Thursday, Saturday; use 1 packet only for each application

 

 

  • External genital warts: Apply prior to normal sleeping hours and leave on skin for approximately 8 hours; then wash with mild soap and water; non-occlusive dressings such as cotton gauze/underwear may be used in management of skin reactions

 

 

  • Zyclara can be used daily on larger surface areas than Aldara
  • Actinic keratosis: Do not extend specified treatment cycle due to missed doses or rest periods

 

 

  • External genital warts: Apply prior to normal sleeping hours and leave on skin for approximately 6-10 hours; then wash with mild soap and water; nonocclusive dressings such as cotton gauze/underwear may be used in management of skin reactions
  • Do not bandage application area
  • Wash hands before and after application
  • Zyclara Pump: Prime before first use only by repeatedly depressing actuator until cream is dispensed
  • Avoid use in or on lips, nostrils or eyes

 

Systemic Reactions: All Indications

Patients may experience flu-like systemic signs and symptoms during treatment with Aldara Cream (even with normal dosing). http://www.tabletwise.com/southafrica/aldara-cream Systemic signs and symptoms may include malaise, fever, nausea, myalgias and rigors . An interruption of dosing should be considered.

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